Endocrine Abstracts

As days become shorter susceptible people typically develop a cluster of symptoms associated with seasonal affective disorder (SAD): decreased energy levels, difficulty waking up, increased sleeping, weight gain, social withdrawal, difficulty concentrating and depressed mood. These symptoms usually remit in the spring with the increase in photoperiod. There is also evidence for seasonality (i.e. less severe changes in mood than observed in SAD) in the general population. SAD i...

Summary: Physiological replacement of glucocorticoids in hypocortisolemic patients remains a challenge. We assessed the use of salivary cortisol and total serum cortisol profile with CBG measurement in monitoring glucocorticoid replacement in hypoadrenal patients in routine clinical practice.Methods: Serum and salivary cortisol concentrations were measured in 60 hypoadrenal patients previously documented to have cortisol deficiency on provocative testing...